57
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17731 |
CL2A-SN-38
|
Others | Others |
CL2A-SN-38 是一种药物-接头偶联物,由一种有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成,用于制造抗体药物偶联物。它对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 | |||
T68896 |
Daniquidone
NSC 320846,BAY-H 2049 |
Topoisomerase | DNA Damage/DNA Repair |
Daniquidone (Batracylin) 是一种有效的 DNA 拓扑异构酶 I 和 DNA 拓扑异构酶 II 双重抑制剂, 具有细胞毒性和抗增殖活性,可诱导 DNA 断裂,可用于研究肿瘤、免疫系统疾病和淋巴系统疾病。 | |||
T6336 |
Amonafide
NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed |
Topoisomerase | DNA Damage/DNA Repair |
Amonafide (NSC-308847,AS1413) 是一种拓扑异构酶 II 的抑制剂和 DNA 的嵌入剂,通过拓扑异构酶 II 介导的反应产生蛋白质相关的 DNA 链断裂 | |||
T15168 |
DRF-1042
|
Others | Others |
DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype. | |||
T31011 |
Coralyne chloride
|
Topoisomerase | DNA Damage/DNA Repair |
Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物,是一种基于荧光 DNA 的分子整流剂,通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子,诱导拓扑异构酶 I 介导 DNA 裂解。 | |||
TQ0088 |
Exatecan Mesylate
依沙替康甲磺酸盐,依喜替康甲磺酸盐,DX8951f |
Topoisomerase | DNA Damage/DNA Repair |
Exatecan Mesylate (DX8951f) 是一种 DNA 拓扑异构酶 I 抑制剂,IC50值为 2.2 μM,可研究癌症。 | |||
T11249L |
Dxd
Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ |
Topoisomerase | DNA Damage/DNA Repair |
Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂,IC50值为 0.31 μM,用作HER2靶向ADC 的偶联药物。 | |||
T11872L |
LMP744 hydrochloride
NSC706744 hydrochloride,MJ-III65 hydrochloride |
Topoisomerase | DNA Damage/DNA Repair |
LMP744 hydrochloride (NSC-706744 hydrochloride) 是一种是拓扑异构酶 1 抑制剂,显示出抗肿瘤的活性。 | |||
T11249 |
Exatecan
依喜替康,DX-8951,DX-8951f |
Topoisomerase | DNA Damage/DNA Repair |
Exatecan (DX-8951f) 是一种 DNA 拓扑异构酶 I (TOP1) 抑制剂,IC50 值为 2.2 μM (0.975 μg/mL)。Exatecan 具有抗肿瘤活性,可用于癌症研究。 | |||
T7309 |
TAS-103 dihydrochloride
6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride |
Topoisomerase | DNA Damage/DNA Repair |
TAS-103 dihydrochloride (BMS-247615 dihydrochloride) 是可用于癌症研究的一种 DNA 拓扑异构酶 I/II 双重抑制剂。 | |||
T17731L |
CL2A-SN-38 DCA 1279680-68-0(free base)
|
Others | Others |
CL2A-SN-38 DCA 1279680-68-0(free base) 是一种药物-接头偶联物,由有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成,用于制造抗体药物偶联物 (ADC)。CL2A-SN-38 由有效的 DNA 拓扑异构酶组成I 抑制剂 SN-38 和接头 CL2A 以制造抗体药物偶联物 (ADC)。 CL2A-SN-38 对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 CL2A 是一种不可切割的复杂 PEG8 和含有三唑的 PABC-肽-mc 接头。 CL2A 可通过 pH 敏感性裂解,产生旁观者效应,并通过二硫键在半胱氨酸残基处结合抗体。 | |||
T29168 |
XR-5000
NSC-601316,CRC8805,SN-22995,DACA,CRC-8805 |
||
XR-5000 is a DNA topoisomerase I and II inhibitor. | |||
T11872 |
LMP744
NSC706744,MJ-III65 |
Others | Others |
LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. | |||
T15586 | Intoplicine | Topoisomerase | DNA Damage/DNA Repair |
Intoplicine is an inhibitor of DNA topoisomerase I and II. | |||
T60617 | Topoisomerase I inhibitor 2 | ||
Topoisomerase I inhibitor 2 是一种高度选择性的DNA 拓扑异构酶 I(Top1) 抑制剂,可抑制Top1活性并导致 DNA 损伤。Topoisomerase I inhibitor 2 阻断 G2/M 期并诱导细胞凋亡,具有抗肿瘤作用。 | |||
T70445 |
Lurtotecan dihydrochloride
|
||
Lurtotecan dihydrochloride is an antineoplastic (DNA Topoisomerase I Inhibitor) | |||
T72727 |
Huanglongmycin N
|
||
Huanglongmycin N为DNA拓扑异构酶I (DNA topoisomerase I) 抑制剂,表现出EC50值为14 μM。 | |||
T69838 | NB-506 glucuronide | ||
NB-506 glucuronide is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor. | |||
T60766 |
Topoisomerase I inhibitor 3
|
||
Topoisomerase I inhibitor 3 (Compound ZML-14) 诱导 HepG2 细胞凋亡,并在 G2/M 期阻滞细胞周期。Topoisomerase I inhibitor 3 是与拓扑异构酶 I-DNA 复合物相互作用的拓扑异构酶 I 抑制剂。 | |||
T28982 |
TLC 388
TLC-388,TLC388 |
||
TLC 388, a DNA topoisomerase I inhibitor, is used potentially for the treatment of Renal carcinoma and Hepatocellular carcinoma | |||
T40365 | T-2513 | ||
T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis. | |||
T26339 |
XR-11576
MLN-576,MLN 576,MLN576,XR 11576 |
||
XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors. | |||
T39373 |
PNU-EDA-Gly5
PNU-EDA-Gly5 |
||
PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5. | |||
T61501 |
Topoisomerase I inhibitor 5
|
||
Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1]. | |||
T70513 | NB-506 Free Base | ||
NB-506 Free Base is an indolocarbazole antitumor agent; a DNA topoisomerase I inhibitor. | |||
T15200 |
Edotecarin
PF 804950,J 107088 |
Topoisomerase | DNA Damage/DNA Repair |
Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM). | |||
T63225 | T-2513 hydrochloride | ||
T-2513 hydrochloride 是拓扑异构酶 I (topoisomerase I) 的选择性抑制剂。T-2513 hydrochloride 能够共价结合拓扑异构酶 I-DNA 复合物,保持其稳定性,并能够抑制 DNA 复制和 RNA 合成,导致细胞死亡。 | |||
T36700 | CKD 602 | ||
Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo. | |||
T62094 | Topoisomerase I inhibitor 6 | ||
Topoisomerase I inhibitor 6 (Compound 3) 是一种 Topoisomerase I 的有效抑制剂,可以捕获 DNA-Top1 裂解复合物,在非癌细胞系中具有较小的细胞毒性。Topoisomerase I inhibitor 6 对癌症疾病表现出潜在的研究价值。 | |||
T10832 | CL2-SN-38 | Others | Others |
CL2-SN-38, a part of the antibody-drug conjugate (ADC), can conjugate with the anti-Trop-2-humanized antibody hRS7. SN-38 is an inhibitor of DNA topoisomerase I. | |||
T61045 | Topoisomerase I/II inhibitor 2 | ||
Topoisomerase I/II inhibitor 2 (compound 1a) 可显著抑制小鼠模型中的异种移植肿瘤的生长,可用于肝癌治疗。Topoisomerase I/II inhibitor 2 是一种DNA 拓扑异构酶 I/II 的双重抑制剂。Topoisomerase I/II inhibitor 2 是有效的拓扑异构酶抑制剂,对LM9 细胞和Huh7 细胞的 IC50值分别为 6.83 μM 和9.82 μM 。 | |||
T78630 |
Exatecan mesylate dihydrate
DX-8951 mesylate dihydrate |
Topoisomerase | DNA Damage/DNA Repair |
Exatecan (DX-8951) mesylate dihydrate 是 DNA topoisomerase I 抑制剂,其 IC50 为 2.2 μM (0.975 μg/mL),用于癌症研究。 | |||
T38731 |
Intoplicine dimesylate
RP 60475 dimesylate |
||
Intoplicine (RP 60475) dimesylate is a DNA topoisomerase I and II inhibitor belonging to the 7H-benzo[e]pyrido[4,3-b]indole series. It exhibits a strong affinity for DNA (K A = 2 x 10^5 /M), resulting in increased linear DNA length. | |||
T23654 |
Afeletecan free base
BAY 56-3722,BAY56-3722,BAY-563722,Afeletecan |
||
Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collis | |||
T74724 | MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan | ||
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan 是抗体偶联活性分子的一部分 (drug-linker conjugate for ADC),包含 Exatecan 。Exatecan 是一种 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 (IC50=2.2 μM)。 | |||
T79883 |
9-Chloromethyl-10-hydroxy-11-F-Camptothecin
|
Topoisomerase | DNA Damage/DNA Repair |
9-Chloromethyl-10-Hydroxy-11-F-Camptothecin是一款喜树碱类衍生化合物,具有DNA拓扑异构酶I (Topo I)抑制活性,应用于癌症治疗的研究领域。 | |||
T38962 |
MC-SN38
MC-SN38 |
||
MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks. | |||
T74723 | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan | ||
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan 是一种抗体偶联活性分子的一部分 (drug-linker conjugate for ADC),包含 Exatecan 。Exatecan 是一种 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 (IC50=2.2 μM)。 | |||
T16024 |
MC-GGFG-DX8951
|
Others | Others |
MC-GGFG-DX8951 is a drug-linker conjugate designed for antibody-drug conjugation (ADC) that demonstrates antitumor activity through the deployment of DX8951, a DNA topoisomerase I inhibitor, connected using the protease-cleavable MC-GGFG linker[1]. | |||
T27141 |
Delimotecan
MEN4901,MEN 4901,T-0128,MEN-4901,T 0128 |
||
Delimotecan is a DNA topoisomerase I inhibitor. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil count significantly correlated with | |||
T77901 |
Ac-Exatecan
|
Topoisomerase | DNA Damage/DNA Repair |
Ac-Exatecan是经乙酰化改良的Exatecan,后者(DX-8951)为ADC生产中普遍使用的毒素组分(ADC Cytotoxin),同时作为DNA拓扑异构酶I(topoisomerase I)的抑制剂,其IC50值为2.2 μM。 | |||
T18538 |
MAC glucuronide phenol-linked SN-38
|
Others | Others |
MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1]. | |||
T62435 |
Belotecan
|
||
Belotecan (CKD-602 free base) 是一种 DNA topoisomerase I 抑制剂。Belotecan 能够阻滞细胞周期,并诱导细胞凋亡。Belotecan 是一种具有抗肿瘤作用的喜树碱衍生物,能够用于研究癌症。 | |||
T68207 |
Elsamitrucin
|
||
Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). | |||
T14945 |
CH-0793076
TP3076 |
Topoisomerase | DNA Damage/DNA Repair |
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM). | |||
T77889 |
NH2-methylpropanamide-Exatecan TFA
|
Topoisomerase | DNA Damage/DNA Repair |
NH2-methylpropanamide-Exatecan (TFA) 为对异丁酰胺进行修饰的Exatecan,属于ADC毒素(ADC Cytotoxin),应用于ADC合成中。该化合物作为DNA拓扑异构酶I(topoisomerase I)抑制剂,具有2.2 μM(0.975 μg/mL)的IC50,适用于癌症研究。 | |||
T77891 |
Propargyl-PEG4-GGFG-DXd
|
||
Propargyl-PEG4-GGFG-DXd 作为抗体偶联活性分子(drug-linker conjugate for ADC)的组成部分,整合了一个可降解的ADC linker与 DNAtopoisomerase I 抑制剂 DXd。 | |||
T36485 |
Becatecarin
|
||
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2. | |||
T77882 |
SN38-COOH
|
||
SN38-COOH 是合成抗体-活性分子偶联物 (ADC) 的关键中间体。SN-38 作为伊立替康的活性代谢物,主要功能是抑制拓扑异构酶 I,从而阻碍 DNA 和 RNA 的合成。 | |||
T77847 |
MC-Val-Cit-PAB-Exatecan
MC-Val-Cit-PAB-DX8951 |
||
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) 是一种抗体-活性分子偶联物(ADC)的关键部分,由 DNA 拓扑异构酶 I 抑制剂 DX-8951 和组织蛋白酶敏感的连接子共同构成。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1123 |
Camptothecin
NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT |
Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal | Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology |
Camptothecin (CPT) 属于生物碱类天然产物,是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM),具有特异性。Camptothecin 具有抗肿瘤活性,可以诱导细胞凋亡。 | |||
T6407 |
β-Lapachone
3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501 |
IDO; Apoptosis; Topoisomerase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism |
β-Lapachone (ARQ-501) 是一种萘醌类天然产物,是拓扑异构酶 I 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。 | |||
TQ0134 |
Podocarpusflavone A
|
Topoisomerase | DNA Damage/DNA Repair |
Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7. | |||
T5853 |
Rubitecan
RFS 2000,鲁比特康,9-Nitrocamptothecin |
Topoisomerase | DNA Damage/DNA Repair |
Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物,具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂,以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。 | |||
T5784 |
Topotecan
NSC 609669,拓扑替康,SKF 104864A |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂,通过抑制 DNA 拓扑异构酶起抗肿瘤作用,可用于治疗卵巢癌。 | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
T1703 |
SN-38
7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38 |
DNA/RNA Synthesis; Topoisomerase; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物,可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性,可以诱导细胞自噬。 | |||
T6228 |
Irinotecan
CPT-11,Topotecin,伊立替康,(+)-Irinotecan |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Irinotecan (CPT-11) 是喜树碱的衍生物,是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接,并导致双链 DNA 断裂和细胞死亡,具有抗肿瘤活性。 | |||
T0486L |
Irinotecan Hydrochloride
盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride |
Topoisomerase; Autophagy | Autophagy; DNA Damage/DNA Repair |
Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐,是一种拓扑异构酶 I 抑制剂,可研究结肠癌和直肠癌。 | |||
TN1037 |
Groenlandicine
|
Topoisomerase | DNA Damage/DNA Repair |
Groenlandicine 是来自黄连的一种原小檗碱生物碱,能诱导拓扑异构酶 I 介导的 DNA 裂解。它对人类重组醛糖还原酶(HRAR)具有中度的抑制作用,IC50值为 154.2 μM。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T3339 |
Sophoridine
5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物,诱导细胞凋亡。 | |||
T16726 |
Rebeccamycin
|
Topoisomerase | DNA Damage/DNA Repair |
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II. | |||
T72236 |
erythro-Austrobailignan-6
|
||
erythro-Austrobailignan-6 是一种口服活性的抗癌化合物,能够抑制 DNA 拓扑异构酶 I 及 II 的活性,同时诱导细胞凋亡并增加 p38 和 JNK 的磷酸化。 | |||
T1521 |
(±)-10-Hydroxycamptothecin
Hydroxy Camptothecine,10-羟基喜树碱,10-Hydroxycamptothecin |
Topoisomerase | DNA Damage/DNA Repair |
(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) 是一种从喜树茎木中分离出来的生物碱,抑制拓扑异构酶 I 活性,具有广谱抗肿瘤活性。 | |||
TN4283 | Isodiospyrin | Topoisomerase; Antifection | DNA Damage/DNA Repair; Microbiology/Virology |
Isodiospyrin is a novel human DNA topoisomerase I inhibitor, it exhibits cytotoxic activity to tumor cell lines. Isodiospyrin has antibacterial activity, the minimum inhibitory concentrations (MICs) against Gram-positive bacteria ranged from 0.78 to 50 mi | |||
T1456 |
Doxorubicin
Hydroxydaunorubicin,阿霉素,Adriamycin |
Topoisomerase; AMPK | Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。 |